Systematic treatment of fundamental chemical and physical principles and their applications to the properties and transformations of materials, including the concept of energy and its uses, gas laws, kinetic molecular theory, laws of chemical combination, atomic and molecular structure, periodic classification of the elements, and chemical bonding. Prerequisite, two years of high school mathematics, one of high school chemistry, and one year of high school physics, or permission of instructor. Students who register for Chem 111A are required to register for one of the subsections. Exams at which attendance is required will be given from 6:30 to 8:00 p.m. on Tuesdays September 29, October 27, and December 1.
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This course provides an introduction to basic laboratory techniques and experimental method, as well as direct experience with chemical principles and the properties and reactions of substances. The course is designed to be taken concurrently with the first semester of the general chemistry lecture series (Chem 111A). Students attend a lab lecture every Monday and perform experiments every week as scheduled. The first lab lecture is scheduled for August 24. Students with less extensive chemistry backgrounds are strongly encouraged to attend an extra lecture held on Friday, August 28 at 3 pm. Lab starts on the week of Sept. 8-Sept 12. Students should pay careful attention to the Fall calendar for special events such as religious holidays, athletic activities, and other travel when selecting a laboratory section. A mid-term exam at which attendance is required will be given from 6:30-8:30 pm on Wednesday, October 14. Prerequisite: concurrent enrollment in Chem 111A or permission of the instructor.
A weekly lecture by a chemistry faculty member, or other scientist from academia or industry, on their current research activities.
Current Challenges in Energy and the Environment
This course is designed to provide an overview of chemistry as it relates to problems in environmental science, energy, and related topics. It is constructed such that all students, irrespective of their major area of study, can learn about chemistry in these contexts. The course is intended to be highly interdisciplinary; therefore, it will cover subjects including chemistry, physics, engineering, geology, biology, environmental policy, and others.
Organic Chemistry I With Lab
The first part of a two-semester survey of organic chemistry lecture and lab. The course will include an introduction to organic structures, reactions, and reaction mechanisms. The laboratory is an introduction to methods in organic chemistry including separation and methods of purification of organic compounds. See syllabus for lab meeting schedule. Students should pay careful attention to the Fall calendar for special events such as religious holidays, athletic activity, and other travel, when selecting a laboratory section. Prerequisite, Chem 112A, Chem 152. Exams at which attendance is required will be given from 6:30 to 8:30 p.m. on Mondays, September 21, October 12, November 2, and November 23.
Chemical Laboratory Safety
An overview of current laboratory safety, regulatory, and compliance practices. Safety and compliance issues that impact chemical, biological, and materials research will be covered.
Advanced Organic Laboratory
A lecture/laboratory course providing hands-on training in synthetic organic chemistry. Experimental techniques covered will include: flash and thin-layer chromatography, vacuum distillation, handling air-sensitive chemicals under inert atmosphere, independent use of NMR spectrometer and spectra interpretation. Students will also learn to search databases, read primary literature, keep records in lab notebooks and write reports and research proposals. Prerequisite: Chem 262. Six laboratory hours per week. Lectures held three hours a week for the first half of the semester.
Physical Science in 12 Problems
Exercises related to general chemistry, classical mechanics, quantum mechanics, statistical mechanics, thermodynamics, and kinetics, will be solved with numerical software. Each exercise will be accompanied by a lecture, a software template solving a problem and a related take-home problem. The software will allow us to focus on, and treat in a transparent fashion, physical problems without the unworldly idealizations and contrivances found in textbooks. Prerequisites: General Chem, concurrent enrollment with Chem 401 and prior or concurrent enrollment in General Physics.
Physical Chemistry I
Introduction to quantum chemistry (with applications to elementary spectroscopy) and kinetics. Prerequisites: Chem 111A-112A, Math 233; prior completion of Physics 117A and 118A or 197 and 198 is strongly encouraged (but concurrent enrollment in Physics I will be accepted); or permission of instructor. Required course for all Chemistry majors. Exams at which attendance is required will be given from 6:30 to 8:30 p.m. on Mondays September 28, October 26, and Thursday November 19.
Nuclear and Radiochemistry Lab
Application of radiochemical techniques to problems in chemistry, physics, and nuclear medicine. Prerequisites: 3 units of physical chemistry or permission of instructor. One lecture hour and five hours of laboratory a week.
Organic Chemistry III
A lecture course that builds on the material in Chem 261-262, covering in more detail certain topics in those courses while also introducing new topics. A transition to graduate level study in organic chemistry; recommended for chemistry, biochemistry, and biology majors. Prerequisite, Chem 262.
The focus of this course in an overview of Modern Medicinal Chemistry from the selection of a therapeutic target through the FDA-approval process. Each aspect will be exemplified by examples of drugs currently in clinical use, or in late-stage development. One aspect of particular interest to synthetic chemists is the underlying development chemistry that often determines the competitive success of a product. Topics to be covered include peptidomimetic HIV protease inhibitors, topoisomerase inhibitors, HMGCoA-reductase inhibitors (Lipitor, etc.), receptor tyrosine-kinase inhibitors (Gleevac, etc.), a synthetic mimetic of superoxide dismutase, and several others depending on the interests of the participants. Students will be responsible for presenting to the class the synthetic routes developed for the discovery and commercialization of these drugs focusing on development chemistry. Prerequisite: Chem 262.
Survey of organometallic compounds with discussion of their synthesis, structure, spectroscopy, and reactivity. Prerequisite: Chem 262.
Introduction to modern inorganic chemistry; emphasis on relation of structure and bonding to the chemical and physical properties of compounds. Prerequisites: Chem 111A required and Chem 112A recommended , or permission of instructor.
Solid-State and Materials Chemistry
The course begins with basic crystallography and introduces common inorganic structure types as well as some common defects in crystalline solids. Students are then taught to use phase diagrams to assess the compositions and microstructures of materials produced by various synthetic and processing methods. The relation between the atomic structure of a solid and it's resulting chemical reactivity and physical properties (e.g. optical, electrical, and mechanical) will be discussed throughout the semester. The thermodynamics and kiinetics of solid-state structural transformations and reactions (e.g. crystal nucleation and growth, alloying, oxidation,and ion intercalation/exchange) will also be explored. Prerequisites, Chem 111A-112A.
General Biochemistry I
The first part of a two-semester survey of biochemistry. This course covers biological structures, enzymes, membranes, energy production and an introduction to metabolism. Prerequisites: Biol 2970, Chem 262.
Biological Chemistry Seminar
This course is required for all graduate students following the biological chemistry track. The course will consist of tutorials for first year graduate students and research presentations by second year students. Prerequisites: enrollment in the biological chemistry track or permission of the instructor.
Inorganic Chemistry Seminar
Students present informal seminars on topics of current interest from the chemical literature or from their own dissertation research.
Special Topics in Inorganic Chemistry: The Chemistry of Energy Storage
Renewable sources of energy and hybrid vehicles have gained popularity due to the rising environmental crisis caused by the emission of greenhouse gases. Lucky for humans, both wind and solar energy can be captured, stored, and reused at a later time in order to power vehicles, portable electronics, and homes via electrochemical energy storage technologies. Furthermore, energy storage devices possessing extended cyclability capable of instantaneously delivering bursts of electricity, and featuring a high-power energy density, are ideal candidates for controlling interruptions in the transmission of electricity in grids. Not surprisingly, this field of study is very important to society and is the focus of research for a large and vibrant scientific community spanning globally across national laboratories, universities, and private industries. A key component that enables the development of state-of-the-art devices is the synthesis and application of nanostructured materials such as carbon allotropes, metal oxides, and conducting polymers. These nanostructured materials afford enhanced properties such as surface area, directional transport, and conductivity for increasing the efficiency of energy storage. This course will provide an introduction to current synthetic protocols and applications of nanostructured organic, inorganic, and composite materials typically utilized for storing energy. We will focus on the structure and property relationships that are desired for attaining state-of-the-art performance in both pseudocapacitive and capacitive materials. Material characterization via spectroscopy as well as via electrochemical techniques such as cyclic voltammetry, galvanostatic charge/discharge curves, and electrochemical impedance will be a focus during discussions. Current trends in engineering for device fabrication will also be explored in order to understand how to develop energy storage technologies characterized by both high power density and high energy d
Study of statistical mechanical methods and principles, and their connection to thermodynamics. Application to problems of chemical interest, including phase transitions, chemical equilibria, transport and diffusion, liquid structure, solvation, and reaction kinetics and equilibria. Modern computational methods will be reviewed and applied. Prerequisite: Chem 401 and 402 (or equivalent) or permission of the instructor.
Quantum mechanical and classical aspects of paramagnetism and of nuclear and electronic magnetic resonance. Phenomenological equations of motion, spin intractions, spin temperature, thermal relaxation, dynamic polarization, multiple resonance phenomena.