This course provides an introduction to basic laboratory techniques, the experimental method, and the presentation of scientific data as well as direct experience with chemical principles and the properties and reactions of substances. The topics and experiments in this course complement the material covered in the Chem 112A lecture course. Students attend one one-hour laboratory lecture every Monday and a 3-hour lab sessions every week during the semester. Prereqs.: Chem 111A, 151, and concurrent enrollment in Chem 112A or permission of the instructor. STUDENTS REGISTERING FOR CHEM 112A SHOULD REGISTER FOR CHEM 152. The first lecture for this course will be held on Jan. 12. The dates and locations for the mid-term and final exams for all students will be announced and listed on the course homepage. A mid-term exam at which attendance is required will be given from 6:30 to 8:30 p.m. on Wednesday, March 18.
Organic Chemistry II with Lab
A course covering certain areas of organic chemistry in more detail than the prerequisite course, with special emphasis on the mechanisms and the synthetic applications of organic reactions and on the organic chemistry of biological compounds. The laboratory will include organic synthesis and spectroscopic techniques. Required course for chemistry majors. Prerequisite, Chem 261. Exams at which attendance is required will be given from 6:30 to 8:30 pm on Wednesdays, February 4 and 25, March 25, and April 22.
Physical Chemistry II
Introduction to chemical thermodynamics, statistical mechanics, and transport phenomena. Required course for all Chemistry majors. Prereqs.: Chem 111A-112A, Chem 401, Math 233, prior completion of Physics 117 and 118 is strongly encouraged (but prior completion of Physics 117 and concurrent enrollment in Physics 118 will be accepted); or permission of instructor. Exams at which attendance is required will be given on Wednesdays, February 11 and March 25.
Simulation in Chemistry and Biochemistry
This course explores a wide range molecular modeling techniques and applications of computational chemistry to problems in chemistry and biochemistry. Topics include ab initio quantum mechanics, semi-empirical MO theory, molecular mechanics, molecular dynamics simulation, coarse-grained models, electrostatic methods and biomolecular structure prediction. A major component of the course is weekly laboratory sessions using common software programs in the field, including Spartan, Q-Chem, Gaussian, VMD, TINKER, APBS, AutoDock, SDA7 and others. Many of the lab exercises target proteins, nucleic acids and other biological structures. As a final lab experience, students will complete an independent project using tools covered in the course.
Introduction to the Atomic Nucleus
This course is an introduction to the atomic nucleus, radioactivity and the interaction of radiation with matter. Basic models for nuclear stability and structure are presented. All nuclear decay modes are thoroughly discussed as are how all forms of ionizing radiation interact with matter. Selected applications in biology, chemistry, physics, earth science, and medicine are discussed. Some of the technical issues and problems with nuclear power and nuclear waste are also presented. Prerequisites: calculus, and general chemistry or physics.
Instrumental Methods: Physical Chemistry
A course providing direct hands-on experience with the principles of physical chemistry (thermodynamics, quantum, kinetics) and associated experimental methods and instrumentation, including optical, infrared, and nuclear and electron spin resonance, electrochemistry, calorimetry, laser kinetics, and basic electronics. Prerequisite: Chem 401 or concurrent enrollment in Chem 402. Chemistry majors will be given priority enrollment in the course.
A molecule-centered perspective is presented on the current state of the art in antibiotic drug discovery. The molecular mechanisms of drug action and pathogen resistance will be covered along with the chemical and biosynthetic origins of antimicrobial drugs. Prerequisite: Chem 262.
A class in biological chemistry that emphasizes the role of metals in electron transfer and enzymatic catalysis. After a brief survey of essential concepts from biology, coordination chemistry, and spectroscopy, topics will include: electron transfer systems; oxygen transport and activation; metal ion acquisition, transport, and homeostasis; enzymes catalyzing atom transfer reactions and radical-mediated processes. Prerequisite: Chem 252; Chem 461 recommended but not required.
Inorganic Chemistry Laboratory
A laboratory course emphasizing both the synthesis of inorganic compounds and the study of their physical properties. Laboratory exercises will introduce novel synthetic techniques such as high-temperature synthesis and vacuum line manipulations. Compounds will be spectroscopically characterized by UV-visible, gas-phase infrared, and multinuclear and dynamic NMR spectroscopy. Measurements of electrochemical behavior, magnetic susceptibility, and electrical conductivity will be performed. Prereq: Chem 461 or consent of the instructor.
A laboratory course emphasizing both the synthesis of inorganic compounds and the study of their physical properties. Laboratory exercises will introduce novel synthetic techniques such as high-temperature synthesis and vacuum line manipulations. Compounds will be spectroscopically characterized by UV-visible, gas-phase infrared, and multinuclear and dynamic NMR spectroscopy. Measurements of electrochemical behavior, magnetic susceptibility, and electrical conductivity will be performed. Prereq: Chem 461 or consent of the instructor. This course satisfies the Writing Intensive requirement.
Computation Chemistry and Molecular Modeling
Lectures will cover the background, practice and applications of computational chemistry to the modeling of the structures and chemical reactions of organic molecules. Different levels of calculation will be presented, from molecular mechanics calculations and Hhckel molecular orbital theory, through semi-empirical and ab initio self-consistent field calculations with correlation energy corrections, and density functional theory. Hands-on experience performing calculations is an important element in this course.
General Biochemistry II
Topics include carbohydrate, lipid and amino acid metabolism, signal transduction, transport across membranes, DNA replication and repair, transcription and translation, molecular motors, mechanisms of drug action, and the biosynthesis of natural products, biofuels, and biomaterials. Prereq: Bio 2970 and Chem 262. Not available to students who have credit for Bio 451.
Biological Chemistry Seminar
This journal club covers current work in the area of biological chemistry. Four semesters of this course are required for all graduate students in the biological chemistry tract. Prerequisites: enrollment in the biological chemistry track or permission of the instructor.
Nucleic Acid Chemistry
Structure, synthesis, properties, and interactions of nucleic acids, and the design and synthesis of nucleic acid-based and/or targeted drugs, probes and tools. Topics: primary, secondary, and tertiary structure; topological and thermodynamic properties; biological and chemical synthesis; DNA chips; PCR; site-directed natural and unnatural mutagenesis; chemical evolution (SELEX); ribozymes; phage display; carcinogen, drug and protein interactions; affinity cleaving; ultraviolet light and ionizing radiation damage, DNA repair of mutagenesis; design and synthesis of anti-sense and anti-gene probes and drugs. Extensive use is also made of molecular modeling and the protein databank of nucleic acid structures. Prerequisite, Chem 261 and Chem 262 or equivalent).
Radiochemistry for the Life Sciences
This course will provide an introduction to nuclear science (e.g. radioactive decay, nuclear stability, interactions of radiation with matter) and followed by an overview of how radiochemistry is used in the life sciences. Lectures on radiolabeling chemistry with radionuclides used in medical imaging (single photon emission computed tomography (SPECT) and positron emission tomography (PET) and their applications will be presented. In addition, lectures on radiochemistry with tritium (H-3) and C-14 will also be included. Additional applications include environmental radiochemistry as applied to nuclear waste disposal and biofuels.
Inorganic/Organometallic Chemistry Seminar
Students present informal seminars on topics of current interest from the chemical literature or from their own dissertation research.
Physical Properties of Quantum Nanostructures
This course will explore the physical properties of semiconductor nanomaterials with dimensions that are small enough to give rise to quantum-confinement effects. These effects strongly influence the electronic structures, absorption/emission behavior, and charge-carrier dynamics within quantum wells, rods, wires, dots, and nanotubes. The course begins with an overview of the electronic structure of bulk semiconductors. The theoretical and experimental bases for quantum-confinement effects, which are of considerable fundamental and applied interest, will then be developed. A significant emphasis will be placed on the optical absorption and photoluminescence properties of semiconductor quantum nanostructures. Recent advances and observations as reported in the literature will be emphasized throughout the semester. Prerequisites: Chem 461 and Chem 465, or permission of the instructor. While the course is steered to graduate students in the Chemistry Department, Chemistry undergraduate students, graduate or undergraduate students in Physics, Electrical & Systems Engineering, Energy, Environmental & Chemical Engineering, Mechanical Engineering & Materials Science may also find this course valuable.
Spectral Methods in Organic Chemistry
A detailed treatment of the structure and stereochemistry of organic compounds with particular emphasis on ultraviolet, visible, infrared, nuclear magnetic resonance, and mass spectroscopic techniques for structure determination.
Organic Chemistry Seminar
The organic chemistry graduate students enrolled will each present one seminar on a topic of current interest in the literature.
This course covers the development and application of quantum mechanics as applied to molecular structure and properties. Material to be discussed will include the fundamentals of quantum mechanics; representations; matrix formalisms; applications to model systems; perturbation theory; variational methods; many-electron wavefunctions; Hartree-Fock theory and post-Hartree Fock methods; density functional theory; additional topics and applications. Prereq: Chem 401.
Nuclear Magnetic Resonance Spectroscopy
A course dealing with the quantum and classical description of the nuclear magnetic resonance of an isolated system of two spin-1/2 nuclei. The design of pulsed NMR spectrometers and the Fourier analysis of time-dependent observable magnetization in 1 and 2 dimensions are treated in detail, NMR relaxation in liquids and solids is included phenomenologically. Prerequisite: Physical Chemistry or permission of the instructor.