Structure, synthesis, properties, and interactions of nucleic acids, and the design and synthesis of nucleic acid-based and/or targeted drugs, probes and tools. Topics: primary, secondary, and tertiary structure; topological and thermodynamic properties; biological and chemical synthesis; DNA chips; PCR; site-directed natural and unnatural mutagenesis; chemical evolution (SELEX); ribozymes; phage display; carcinogen, drug and protein interactions; affinity cleaving; ultraviolet light and ionizing radiation damage, DNA repair of mutagenesis; design and synthesis of anti-sense and anti-gene probes and drugs. Extensive use is also made of molecular modeling and the protein databank of nucleic acid structures. Prerequisite, Chem 261 and Chem 262 or equivalent).
Course Attributes: FA NSMAR NSMAS NSM
Section 01Nucleic Acids
INSTRUCTOR: TaylorView Course Listing