Mass Spectrometry Facility

Our Mission

The NIH/NIGMS-supported biomedical mass spectrometry (MS) research facility develops novel MS-based solutions to analytical challenges, and provides service, collaboration, and training for MS-based characterization, identification and quantification of all biomolecular classes extracted from in vitro and in vivo model systems. The MS research facility supports integrated research programs in ion chemistry, protein biophysics, targeted and untargeted proteomics, focused on advancing MS platforms, software, and their analytical capabilities for expanding biological knowledge, and training the next generation of translational scientists interested in biomedical applications of MS.

Our Goals

Establish collaborative research projects with basic and applied investigators at Washington University and other institutions
Develop and provide novel mass spectrometry-based analytical services
Educate and train students/fellows/junior faculty in the use and applications of mass spectrometry
Disseminate our research findings and inform the community about biomedical mass spectrometry

Services

We provide MALDI, ESI-MS accurate mass service, LC-MS, LC-MS/MS, denaturing and native ESI MS for large molecules (e.g., antibodies), DAR measurements, HDX MS, FPOP, chemical footprinting, and cross-linking MS. We also provide a variety of data analysis services using Protein Metrics software (e.g., proteomics database searching, intact analysis, drug-to-antibody ratio calculations). Standard fees for the simpler measurements are found in our fee schedule. For larger projects and more complicated measurements please contact the Resource. Please note that publications resulting from work carried out on instruments or aided by personnel that receive support from the MS resource grant must comply with the NIH Public Access Policy.

View our fee schedule or complete an MS sample analysis form.

If you are not sure about what type of analysis will meet your needs, please consult our "Instrumentation and Ionization Methods" tutorial or contact Henry Rohrs. Please contact Henry if you have questions about current or archived data.