James Janetka

Associate Professor of Biochemistry and Molecular Biophysics
Affiliated Professor of Chemistry
PhD Organic Chemistry, University of Wisconsin-Madison
research interests:
  • Organic Chemistry
  • Biological Chemistry
  • Organic Synthesis
  • Protease
  • lectin
  • drug discovery
  • structure-based design
  • cancer
  • infectious disease
  • metastasis
  • cell-signaling
  • synthesis
  • medicinal chemistry
  • carbohydrate
  • peptdidomimetic
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contact info:

mailing address:

  • 8231 (Medical School Campus)
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Professor Janetka's research interests include Organic Chemistry, Biological Chemistry, Organic Synthesis, Protease, lectin, drug discovery, structure-based design, cancer, infectious disease, metastasis, cell-signaling, synthesis, medicinal chemistry, carbohydrate, and peptdidomimetic

Selected Publications

Totsika, M., Kostakioti, M., Hannan, T. J., Upton, M., Beatson, S. A., Janetka, J. W., Hultgren, S. J., and Schembri, M. A. (2013). A FimH inhibitor prevents acute bladder infection and treats chronic cystitis caused by multidrug resistant uropathogenic Escherichia coli ST131, Journal of Infectious Diseases, 208(6), 921-8. PMID: 23737602.

Han, Z.; Pinkner, J.S.; Ford, B.; Chorell, E.; Crowley, J.M.; Cusumano, C.K.; Campbell, S.; Henderson, J.P.; Hultgren, S.J.; Janetka, J.W. (2012). Lead Optimization Studies on FimH Antagonists: Discovery of Potent and Orally Bioavailable Ortho-Substituted Biphenyl Mannosides. Journal of Medicinal Chemistry, 55, 3945–3959. PMID: 22449031.

Oza, V.B., Ashwell, S., Almeida, L., Brassil, P., Bree, J., Deng, C., Gero, T., Grondine, M., Horn, C., Ioannidis, S., Liu, D., Lyne, P.D., Newcombe, N., Pass, M., Read, J., Ready, S., Rowsell, S., Su, M., Toader, D., Vasbinder, M., Yu, D., Yu, Y., Xue, Y., Zabludoff, S. and Janetka, J.W. (2012). Discovery of checkpoint kinase inhibitor (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by structure based design and optimization of thiophene carboxamide ureas. Journal of Medicinal Chemistry, 55(11), 5130–5142.

Yang, B., Hird, A. W., Russell, D. J., Fauber, B. P., Dakin, L. A., Zheng, X. L., Su, Q. B., Godin, R., Brassil, P., Devereaux, E., and Janetka, J. W. (2012) Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO, Bioorg. Med. Chem. Lett. 22, 4907-4911.

Cusumano, C.K., Pinkner, J.S., Han, Z., Greene, S., Ford, B., Janetka, J.W., Hultgren, S.J. (2011). Treatment and Prevention of Urinary Tract Infection with Orally Active Mannoside FimH Inhibitors. Science Translational Medicine, 3, 109, 1-10. PMID: 22089451.

Han, Z.; Pinkner, J.S.; Ford, B.; Obermann, R.; Nolan, W.; Wildman, S.A.; Hobbs, D.; Ellenberger, T.; Cusumano, C.K.; Hultgren, S.J.; Janetka, J.W. (2010). Structure-Based Drug Design and Optimization of Mannoside Bacterial FimH Antagonists Journal of Medicinal Chemistry, 53, 4779-479. PMID: 20507142.

Aronov, A. M.; Tang, Q.; Martinez-Botella, G.; Bemis, G. W.; Cao, J. R.; Chen, G. J.; Ewing, N. P.; Ford, P. J.; Germann, U. A.; Green, J.; Hale, M. R.; Jacobs, M.; Janetka, J. W.; Maltais, F.; Markland, W.; Namchuk, M. N.; Nanthakumar, S.; Poondru, S.; Straub, J.; ter Haar, E.; Xie, X. L. (2009). Structure-Guided Design of Potent and Selective Pyrimidylpyrrole Inhibitors of Extracellular Signal-Regulated Kinase (ERK) Using Conformational Control. Journal of Medicinal Chemistry, 52, 6362-6368.

Zabludoff, S. D.; Deng, C.; Grondine, M. R.; Sheehy, A. M.; Ashwell, S.; Caleb, B. L.; Green, S.; Haye, H. R.; Horn, C. L.; Janetka, J. W.; Liu, D. F.; Mouchet, E.; Ready, S.; Rosenthal, J. L.; Queva, C.; Schwartz, G. K.; Taylor, K. J.; Tse, A. N.; Walker, G. E.; White, A. M. (2008). AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies. Molecular Cancer Therapeutics, 7, 2955-2966.

James W. Janetka, M. Scott Furness, Xiaoyan Zhang, Andrew Coop, John E. Folk, Mariena V. Mattson, Arthur E. Jacobson, and Kenner C. Rice. Enantioconvergent Synthesis of (-)-(2R, 5S)-1-Allyl-2, 5-dimethylpiperazine, an Intermediate to δ-Opioid Receptor Ligands (2003).  J. Org. Chem, 68(10), 3976-3980.

James W. Janetka, Prakash Raman, Ken A. Satyshur, George R. Flentke, and Daniel H. Rich. Novel Cyclic Biphenyl Ether Peptide β-Strand Mimetics and HIV-Protease Inhibitors (1997). J. Am. Chem. Soc., 119, 441-442.