Janice L. Robertson

Janice L. Robertson

Affiliated Associate Professor of Chemistry and Associate Professor of Biochemistry and Molecular Biophysics (School of Medicine)
Hon. BSc. - University of Toronto, Toronto
PhD - Weill Cornell Graduate School of Medical Sciences, New York
Postdoc - HHMI, Brandeis University, Waltham
View All People

contact info:

Single-molecule studies of membrane protein structure, function and folding in membranes


 

Selected Publications

Bernhardt, N., Ozturk, T.N., Zhang, S. et al. Molecular basis for the regulation of membrane proteins through preferential lipid solvation. Nat Chem Biol (2025). https://doi.org/10.1038/s41589-025-02032-w

Mishra A, Vazquez GD, Robertson JL*. A large-scale evolutionary and structural analysis of CLC channels and transporters. bioRxiv 2025.07.07.663545. accepted, Protein Science (2025)

Henze E, Ehrlich JJ, Robertson JL, Gelsleichter E, Kawate T. “The C-terminal activating domain promotes pannexin 1 channel opening.” Proc Natl Acad Sci U S A. 2024 Dec 17;121(51):e2411898121. doi: 10.1073/pnas.2411898121. Epub 2024 Dec 13. PMID: 39671183. (Abstract)

Ernst M, Mahoney-Kruszka R, Zelt NB, Robertson JL. “A roadmap to cysteine specific labeling of membrane proteins for single-molecule photobleaching studies.” Methods. 2024 Nov 23;234:21-35. doi: 10.1016/j.ymeth.2024.10.013. Epub ahead of print. PMID: 39586432.(Abstract)

Eva Fortea, Sangyun Lee, Rahul Chadda, Yiorgos Argyros, Priyanka Sandal, Robyn Mahoney-Kruszka, Hatice Didar Ciftci, Maria E Falzone, Gerard Huysmans, Janice L Robertson, Olga Boudker & Alessio Accardi (2024). “Structural basis of pH-dependent activation in a CLC transporter” Nat Struct Mol Biol. 2024 Apr;31(4):644-656. doi: 10.1038/s41594-023-01210-5. Epub 2024 Jan 26. (Abstract)

Melanie Ernst, Esam A Orabi, Randy B Stockbridge, José D Faraldo-Gómez & Janice L Robertson (2023). “Dimerization mechanism of an inverted-topology ion channel in membranes” Proc Natl Acad Sci U S A. 2023 Nov 21;120(47):e2308454120. doi: 10.1073/pnas.2308454120. Epub 2023 Nov 13. (Abstract)

Melanie Ernst, Tugba N Ozturk, Janice L Robertson (2023). “A single-molecule method for measuring fluorophore labeling yields for the study of membrane protein oligomerization in membranes” PLoS One. 2023 Jan 20;18(1):e0280693. doi: 10.1371/journal.pone.0280693. eCollection 2023. (Abstract)

Rahul Chadda, Taeho Lee, Robyn Mahoney-Kruszka, Elizabeth G Kelley, Nathan Bernhardt, Priyanka Sandal & Janice L Robertson (2023). “A thermodynamic analysis of CLC transporter dimerization in lipid bilayers” Proc Natl Acad Sci U S A. 2023 Oct 10;120(41):e2305100120. doi: 10.1073/pnas.2305100120. Epub 2023 Oct 3. (Abstract)

George R. Heath, Ekaterina Kots, Janice L. Robertson, Shifra Lansky, George Khelashvili, Harel Weinstein, & Simon Scheuring (2021). “Localization atomic force microscopy” Nature. 2021 Jun;594(7863):385-390. doi: 10.1038/s41586-021-03551-x. Epub 2021 Jun 16. (Abstract)

Melanie Ernst & Janice L. Robertson (2021). “The Role of the Membrane in Transporter Folding and Activity” J Mol Biol. 2021 Jun 15;167103. doi: 10.1016/j.jmb.2021.167103. Online ahead of print.

Rahul Chadda, Nathan Bernhardt, Elizabeth G. Kelley, Susana Cm. Teixeira, Kacie Griffith, Alejandro Gil-Ley, Tuğba N. Öztürk, Lauren E. Hughes, Ana Forsythe, Venkatramanan Krishnamani, José D. Faraldo-Gómez, & Janice L. Robertson (2021). “Membrane transporter dimerization driven by differential lipid solvation energetics of dissociated and associated states” Elife. 2021 Apr 7;10:e63288. doi: 10.7554/eLife.63288. (Abstract)

Kacey Mersch, Tugba N. Ozturk, Kunwoong Park, Hyun-Ho Lim, & Janice L. Robertson (2021). “Altering CLC stoichiometry by reducing non-polar side-chains at the dimerization interface” J Mol Biol. 2021 Feb 20;433(8):166886. doi: 10.1016/j.jmb.2021.166886. Online ahead of print. (Abstract)

Robertson J.L. (2018). “The lipid bilayer membrane and its protein constituents.” J Gen Physiol. 2018 Nov 5;150(11):1472-1483. doi: 10.1085/jgp.201812153. Epub 2018 Sep 25. (Abstract)