Kao's research focuses on the development and application of modern two- and three-dimensional reverse-detected NMR spectroscopy to the studies of biomolecules, including conformational analysis of DNA, and structure-activity relationships of biologically active peptides.
D. Su, J. Kao, M. Gross, and J. Taylor, "Structure Determination of an Inter-strand-type cis-anti Cyclobutane Thymine Dimer Produced in High Yield by UVB Light in an Oligodeoxynucleotide at Acidic pH,'' J. Am. Chem. Soc., 130, 11328-11337 (2008).
Sage Arbor, Jeff Kao, Yun Wu, Garland R. Marshall, "c[D-pro-Pro-D-pro-N-methyl-Ala] adopts a rigid conformation that serves as a scaffold to mimic reverse-turns,'' Biopolymers: Peptide Science, 90(3), 384-393 (2008).
Francesco Nodari, Fong-Fu Hsu, Xiaoyan Fu, Terrence F. Holekamp, Lung-Fa Kao, John Turk, and Timothy E. Holy, "Sulfated Steroids as Natural Ligands of Mouse Pheromone-Sensing Neurons," J. Neurosci., 28, 6407-6418 (2008).
Yunpeng Ye, Min Liu, Jeff L.-F. Kao, Garland R. Marshall, "Design, synthesis, and metal binding of novel Pseudo- oligopeptides containing two phosphinic acid groups," Biopolymers, 89(1), 72-85 (2008).
Zongren Zhang, Mikhail Y. Berezin, Jeff L. F. Kao, André d'Avignon, Mingfeng Bai, Samuel Achilefu, "Near-Infrared Dichromic Fluorescent Carbocyanine Molecules,'' Angew. Chem. Int. Ed., 47(19), 3584-3587 (2008).
F. Hsu, F. Nodari, L.-F. Kao, X. Fu, T. F. Holekamp, J. Turk and T. Holy, "Structural Characterization of Sulfated Steroids That Activate Mouse Pheromone-Sensing Neurons†," Biochemistry, 47 (52), pp 14009-14019 (2008).
F. Wang, R. Tang, J. Kao, S. Dingman and W.Buhro, "Spectroscopic Identification of Tri-n-octylphosphine Oxide (TOPO) Impurities and Elucidation of Their Roles in Cadmium Selenide Quantum-Wire Growth," J. Am. Chem. Soc., 131, 4983-4994 (2009).
Rongsheng E. Wang, Jeffrey L.-F. Kao, Carolyn A. Hilliard, Raj K. Pandita, Joseph L. Roti Roti, Clayton R. Hunt, and John-Stephen Taylor, "Inhibition of Heat Shock Induction of Heat Shock Protein 70 and Enhancement of Heat Shock Protein 27 Phosphorylation by Quercetin Derivatives," J. Med. Chem., 52, 1912-1921 (2009).
Hyeran Lee, Mikhail Y. Berezin, Kevin Guo, Jeff Kao and Samuel Achilefu, "Near-Infrared Fluorescent pH-Sensitive Probes via Unexpected Barbituric Acid Mediated Synthesis," Org. Lett., 11 (1), 29-32 (2009).
Mikhail Y. Berezin, Jeff Kao, Samuel Achilefu, "pH-Dependent Optical Properties of Synthetic Fluorescent Imidazoles," Chem. Eur. J. 15, 3560 - 3566 (2009).