The course provides an overview of key methodologies of contemporary biophysics and biophysical chemistry, covering: 1) Spectroscopic methods routinely used in biochemistry, including absorption, fluorescence, and circular dichroism; 2) Biophysical methods to study intra- and intermolecular protein interactions including solutionstate NMR, FCS, and FRET; 3) Cutting-edge biophysical techniques to study transient proteinprotein/ protein-nucleic acids interactions. A significant emphasis is placed on the principles of quantum mechanics, which underpin all the techniques discussed. The course begins with an introduction to the basics of quantum mechanics, laying a foundation for understanding the core physical principles that govern each method. Throughout the course, we will derive and analyze key formulae essential for comprehending and applying these advanced biophysical techniques effectively.
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