Neurodegeneration
With the aging of the world’s population, neurodegenerative disorders are becoming increasingly more prevalent. There are no effective treatments for these disorders which include Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s disease). To address neurodegeneration, work is ongoing to elucidate the biochemical mechanisms underpinning these disorders as well as to explore new therapeutic avenues for treatments.
Areas of Focus
Protein misfolding • Alzheimer’s disease • Amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s disease) • Parkinson’s disease • Huntington’s disease
Affiliated Faculty
Meredith Jackrel
Biochemistry and biophysics; protein folding, misfolding, and neurodegenerative disease; protein engineering and directed evolution; protein disaggregases and molecular chaperones
Michael Gross
Biological and biophysical chemistry, mass spectrometry, structural proteomics,protein footprinting, FPOP, HDX, native MS, crosslinking, ion mobility
Yusuke Okuno
Biophysical Chemistry, Solution-state NMR, Protein-ligand/protein-protein interactions, Protein hydration, Neurodegenerative diseases
Gary Patti
Biochemistry; Metabolism; Metabolomics; Mass Spectrometry; LC/MS; Mass Spectrometry-Based Imaging; Cancer Metabolism; Cell-Cell Interactions; Metabolic Flux Analysis; Enzyme Kinetics; Stable Isotope Tracing; Organismal Metabolism of Model Animals (Zebrafish)
